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Atlas of Clinical Pathology


Acute Leukemia

Acute Leukemia

 


 

+ve ANA - Homogenous

ANA +VE HOMOGENEOUS

 


 

+ve ANA

+ve ANA

 


 

ANA NUCLEOLAR PATTERN

ANA NUCLEOLAR PATTERN

 


 

ANA+VE SPECKLED

ANA+VE SPECKLED

 


 

ASCARIS OVA

ASCARIS OVA

 


 

AUR RODS IN ACUTE MYELOID LEUKEMIA

AUR RODS IN ACUTE MYELOID LEUKEMIA

 


 

BASOPHIL

BASOPHIL

 


 

EOSINOPHIL

Eosinophil

 


 

CHRONIC LYMPHOCYTIC LEUKEMIA

CHRONIC  LYMPHOCYTIC  LEUKEMIA

 


 

chronic myeloid leukemia

chronic myeloid leukemia

 


 

ELLEPTOCYTOSIS

ELLEPTOCYTOSIS

 


 

ENTAMEBA HISTOLYTICA CYST

ENTAMEBA HISTOLYTICA CYST

 


 

FALCIPARUM GAMETOCYTE

FALCIPARUM  GAMETOCYTE

 


 

GRAM +VE DIPLOCOCCI

GRAM +VE DIPLOCOCCI

 


 

GRAM +VE BACELLI CLOS PERF

G+VE BACELLI CLOS PERF

 


 

LE CELL

LE CELL

 


 

M BAND

M BAND

 


 

MONOCYTE

Monocyte

 


 

MULTIPLE MYELOMA

MULTIPLE MYELOMA

 


 

NEISERIA GONORRHEA GRAM -VE COCCI

NEISERIA GONORRHEA GRAM -VE COCCI

 


 

NEUTROPHIL

NEUTROPHIL

 


 

NEUTROPHILS

NEUTROPHILS

 


SPHEROCYTOSIS

 

SPHEROCYTOSIS

 


 

SPHEROCYTOSIS

SPHEROCYTOSIS

 


 

STAPH IN TISSUE

STAPH IN TISSUE

 


 

T.B BACELLI

T.B BACELLI

Color Atlas of Skin Diseases

Rosacea


rosacea
Rosacea is a congestive blushing and

flushing reaction of the central areas of

the face. It is usually associated with an

acneiform component (papules,

pustules, and oily skin). It usually

occurs in middle-aged and older people.

The cheeks, nose, and chin, on the

entire face, may have a rosy hue.

Burning or stinging often accompanies

episodes of flushing. It is much more

common than lupus erythematosus, with which it is often confused. Rosacea

is distinguished from acne by age, the presence of the vascular component, and

the absence of comedones.


Folliculitis

folliculitis

Folliculitis is characterized by red-ringed

papules and pustules at hair follicles. Gram

negative folliculitis may be spread by

contaminated hot tubs. Gram stain and culture

will help to differentiate bacterial from non

bacterial folliculitis. History is important for

pinpointing the cause of non-bacterial
folliculitis.


Impetigo

impetigo

Superficial honey-colored serous crusts are

characteristic of this disorder. It is usually

caused by a staphylococcus infection. Culture is

rarely reliable.


Seborrheic Keratoses

keratosis

These lesions are benign overgrowths of

epithelium, largely appearing on the torso,

face, and neck. They are seen on almost every

one over the age of 50. The borders are

typically irregular, and they range in color

from beige or gray-white to very dark brown.

These “barnacles” of older skin can number

only a few to as many as hundreds. Although

often raised and dry, they can be flatter and

greasier (seborrheic) in texture.


Granuloma Pyogenicum

Pyogenicum

This is a vascular reactive nodule that develops as

a response to a minor injury. The overgrowth of

capillaries leads to a raised red lump which bleeds

profusely when torn.


Lentigo Simplex

lentigo simplex

These lesions occur on sun-exposed skin, especially

face, arms, and hands. Lesions are flat, and

pigmented in shades of brown, with characteristically

sharp borders. They tend to fade with sun avoidance.


Varicella

varicella

Chicken Pox

The rash is pruritic and most prominent on the face,

scalp and trunk. It appears as multitudes of red

ringed papules and vesicles in varying stages of

development. Crusts eventually form and slough off

in 7 to 14 days. Nondermatomal distribution and

lesions of varying stages distinguish primary

varicella from herpes zoster. Fever and malaise may be mild in children and

much more severe in adults.


Hand, Foot, and Mouth Disease

Hand Foot & Mouth Disease

The disorder is characterized by stomatitis and

vesicular rash on palms of hands and soles of feet. It

is caused by Coxsackieviruses A5, 10, 16. The

development of mouth sores is most troublesome to

adults. The skin lesions are vesicopustules, 0.5 to 5

mm, red-ringed, more oval than round, on palms,

sides of fingers and soles.


Verruca Plana

verruca plana

The numerous discrete lesions, closely set, usually

occur on face, dorsa of hands and shins. Lesions are

flat-topped, slightly elevated, well demarcated,

generally flesh-colored, with a matte-smooth surface.

Lesions tend to spontaneously disappear.


Pityriasis Rosea

Pityriasis Rosea

This disorder is a common, but unexplainable,

reaction. The initial lesion, “herald patch”, is red and

scaly, followed in 1 to 2 weeks by widespread, oval,

scaling, fawn-colored macules 4 to 5 mm in

diameter over the trunk and proximal extremities.

Pityriasis rosea is usually an acute self-limiting

illness that lasts 4 to 8 weeks. It is not highly infectious.


Vesicular Hand Dermatitis

vesicular hand dermatitis

This disorder is a severely pruritic reaction in

individuals with a personal or family history of

allergic manifestations. It is characterized by flares

of congestion resulting in deep and superficial

blisters, followed by peeling, scaling, and a dry,

reddened surface. Flares generally result from

contact with irritants, but stress is also a significant

factor.


Seborrheic Dermatitis

seborheic dermatitis

Seborrheic dermatitis is generally limited to the scalp;

however, dry scales and underlying erythema can

occur on the face, ears, chest, back, and body folds.

Skin may be dry or oily. In infants, a widespread

reaction is associated with minimal discomfort. The

yeast organism, Pityrosporum, may be a factor. Mild

scaling without any erythema is often termed simple

dandruff. Tinea capitis may simulate dandruff or seborrheic dermatitis, and

scrapings should be taken for KOH examination and fungal culture, especially

in children, if hair loss is present.


Nummular Dermatitis

nummular dermatitis

A pruritic dermatosis, characterized by round to oval

(coin-shaped) areas of vesiculation, superficial

crusting, and redness. Number of lesions varies from

few to many. More often this is a symmetrical

pattern in young adults. Not related to atopic

dermatitis.


Tinea Capitis

tinea capitis

Along with hair loss, the scalp surface shows

seborrheic dermatitis-like scaling, impetigo-like

crusting, pustules, inflammatory nodules or kerion.

Identify tinea with KOH culture onto a fungal media.

No longer a disease confined to children. If infection

suspected, all family members should be examined.


Tinea Versicolor

tinea versicolor

Asymptomatic to mildly itchy macules that scale

readily on scraping. Lesions, usually occur on the

trunk, but may appear on upper arms, neck, face,

and groin. Caused by a yeast organism,

Pityrosporum orbiculare. Altered pigmentation can

be very subtle to obvious, both hypo and

hyperpigmented. KOH shows characteristic spores and hyphae. Fungal culture

is not useful.


Candidiasis

candidiasis

Common normal flora, but it may become an

opportunistic pathogen widespread in patients with

AIDS and other immunosuppressed patients.

Mucocutaneous candidiasis occurs on the vulva, anus,

breast or groin folds. Superficial denuded beefy red

areas with or without scattered satellite

vesicopustules with marginal scaling. Microscopic examination with 10%

KOH reveals budding spores and short hyphae.


Erythema Chronicum Migrans

erythema chronicum migrans

Lyme Disease

Caused by the spirochete Borrelia burgdorferi, which

is transmitted to humans by a deer tick bite, infection,

is characterized by erythema migrans. A flat or

slightly raised red lesion appears at the site. The

reaction can become quite large, is generally circular

in shape, and can show several concentric rings

(target pattern). Erythema migrans is often accompanied by flu-like illness

with fever, chills, and myalgias. At this stage, laboratory tests are not reliable.


Actinic Keratoses

actinic keratosis

Actinic keratoses are single or multiple, flesh

colored or slightly hyperpigmented, dry, rough,

scaly lesions which occur on skin exposed to the

sun. Cells are atypical, and they are considered to

be pre-malignant because some may eventually

become squamous cell cancers.


Basal Cell Carcinoma

basal cell carcinoma

This lesion represents 90% of skin cancers. Basal

cell carcinoma is the most common cancer. On the

face, it usually starts as a reddened papule or nodule

with a smooth surface and a translucent, pearly

quality. Because of a poorly formed stroma, it is

fragile and often bleeds. On the torso, the lesion has

an irregular surface, bright red color, sometimes scaly, with a distinct edge.

Histologic examination is required.


Squamous Cell Carcinoma

squamous cell carcinoma

This lesion usually appears on skin that shows other

significant changes of chronic sun exposure.

Especially prevalent in fair-skinned people who

sunburn easily and tan poorly. It may arise out of

actinic keratoses. Characteristically, the lesion

appears fairly rapidly as a small red, conical, hard

nodule. Should it appear on the mucus membrane or lip area, it behaves much

more aggressively and can be fatal. Histologic examination is required.


Malignant Melanoma

malignant melanoma

Recognized through the mnemonic, “A-B-C-D:”

Asymmetry of contour, irregularity of Border and

Color, and Diameter larger than 6 mm. Melanomas

vary from macules to nodules. Color ranges from

flesh tints to pitch black and mixtures of white, blue,

purple, and red. Any pigmented skin lesion with

recent change in appearance should be suspected.

Malignant melanoma can exist in a superficial spreading mode for years and

still be curable by excision with 1 to 2 cm margins. Once a vertical growth

phase develops, rapid spread through blood and lymph vessels occurs.

Histologic examination is required.


Atypical Moles

atypical mole atypical mole atypical mole atypical mole

Dysplastic change implies abnormal cell

development, which does not necessarily imply

precancerous change. These atypical moles, show

irregular outlines, and different shades and patterns

of brown color. If they appear in a person with a

family history of melanoma and are multiple in

number, the incidence of cancer developing reaches

100%. If they are sporadic in pattern and number,

they should be photographed and reexamined

regularly. Histopathologic examination is required.


Psoriasis of the Nails

psoriasis nail

Pitting of nail surface with spots of white to yellow

brown (oil droplets) reflects psoriatic changes in the

nail matrix and nail bed respectively. Distally, there

are irregular onycholysis, splitting, and dystrophic

changes. Onycholysis may simulate onychomycosis;

therefore, fungal culture will be valuable in

diagnosis.


Intertriginous Psoriasis

interiginous psoriasis

Sebopsoriasis

The skin fold areas are shades of red and orange,

with mild to severe itching. The characteristic sign

is the uniform appearance (unlike tinea) and distinct

border (unlike candida). Generally, a complete skin

exam will reveal other signs of psoriasis.


Psoriasis of the Scalp

psoriasis scalp

The lesions are red, sharply defined plaques covered

with thick silvery scales. This distinguishes psoriasis

from the diffuse or patchy redness and scaling of

seborrheic dermatitis.


Pstular Psoriasis

pustular psoriasis

Generally, a chronic, disabling condition of the

palms and soles, it can also be a part of a very

severe generalized reaction.


Guttate Psoriasis

gluttate psoriasis

A form of psoriasis characterized by the rapid

development of myriad small lesions, 3 to 10 mm in

diameter, on all areas of the body, especially the

extremities. More often seen in young people.


Herpes Simplex, Penis

herpes simplex penis

Red, sharply marginated, grouped vesicles usually

become crusted sores within 48 hours. Typical

distribution includes prepuce, coronal sulcus, glans,

shaft. Deep aching pain of the perineum may occur

2 to 3 days before appearance of the skin lesions.

Itchy and painful, lesions generally recur in the

same location.


Herpes Simplex, Vulva

Herpes Simplex, Vulva

Painful, recurrent, grouped vesicles. Viral

shedding occurs even when no lesions are present.

This sexually transmitted disease can complicate

pregnancy.


Herpes Simplex, Perineum

herpes simplex perineum

Recurrence of painful sores is a diagnostic sign.


Herpes Simplex in AIDS

herpes simplex AIDS
Lesion in the perianal area becomes a deeply

ulcerated, very painful, disabling infection.


Condyloma Acuminatum

Condyloma Acuminatum

Genital Warts

Highly contagious and sexually transmitted, soft,

skin-colored, fleshy warts can be pin-head papules

or cauliflower-like masses that are caused by the

human papilloma virus. On the vulva, perianal area,

vaginal walls, cervix, or on the shaft of the penis,

warts can be raised clusters and obviously wart-like, or so small they only

become recognizable after application of 5% acetic acid (vinegar) for ten

minutes. Lesions must be distinguished from condylomata lata caused by

syphilis. Diagnosis of syphilis is based on a positive serologic test or discovery

of Treponema pallidum on darkfield examination.


Secondary Syphilis

secondary syphilis

Generalized maculopapular eruptions are most

common, although lesions may be pustular or

follicular as well (or combinations of any of these

types). Condylomata lata are raised, weeping

papules on the moist areas of the skin and mucous

membranes. The patient generally feels sick, can

have regional lymphadenopathy, but complains only of minimal itching.

Diagnosis of syphilis is based on a positive serologic test or discovery of

Treponema pallidum on darkfield microscopy.


Scabies

scabies

Scabies is a common dermatitis caused by

infestation with Sarcoptes scabiei. The entire

family may be affected. Skin lesions are scattered

groups of pruritic vesicles and pustules in “runs” or

“burrows” on the sides of the fingers, palms, wrists,

elbows, axillae, as well as around the waist and

groin. Itching occurs almost exclusively at night.

Microscopic examination of a scraping will reveal scabies mites, ova, and

feces.


Pediculosis

pediculosis

Lice

Pediculosis is a parasitic infestation of the skin of the

scalp, trunk, or pubic areas. Itching may be very

intense and scratching may result in deep

excoriations over the affected area. Head lice are

easiest to see above the ears and at the nape of the neck. The nits (egg sacs) are

attached to hairs, close to the skin. Body lice deposit visible nits on vellus hair.

Head and body lice are similar in appearance and are 3 to 4 mm long.


Papular Urticaria

papular urticaria

Almost exclusively in children, this is a widespread

reaction to insect bites such as fleas, bedbugs,

chiggers, or gnats, and may persist for long periods.

The tendency will fade with onset of adolescence.


Urticaria

urticaria

Usually intensely itching intradermal vascular

reaction (wheals or hives). No epidermal changes

such as scaling, papules, or blisters. More often has

an unknown, nonspecific etiology, but can be

related to medications, foods, and similar vascular

stimulating agents. Laboratory studies are not likely

to be helpful in evaluation unless there are sugges

tive findings in the history and physical examination.


Molluscum Contagiosum

molluscum contagiosum

Caused by a large pox virus, these smooth-walled,

dome-shaped, pearly papules, 2 to

5 mm in size, have an umbilicated center.

Occasionally a significant inflammatory reaction

will occur. Principal sites are face, hands, lower

abdomen, and genitals. A common viral infection

seen in AIDS. It is more difficult to eradicate in

these patients.


Herpes Simplex

herpes simplex

Small red-ringed blisters can occur anywhere,

especially around oral and genital areas. Associated

and often preceded by burning and stinging.

Regional lymph nodes may be swollen and tender.

Blisters rupture early, leaving serous crusts which

can then become secondarily infected. Viral cultures

and ELISA are positive.


Herpes Zoster

herpes zoster

Red-ringed blisters occur in a dermatomal

distribution of a nerve root. Papules change to

vesicles which become pustules before crusting.

New lesions appear for up to one week. Regional

lymph glands may be tender and swollen. Since this

is primarily a nerve infection with secondary skin

manifestations, it is preceded, accompanied, and

followed by pain. In elderly patients, it is often severe and prolonged. In

immunosuppressed patients, herpes zoster may disseminate, producing lesions

beyond the dermatome, visceral lesions, and encephalitis. Disseminated Zoster

is a serious, sometimes life-threatening complication.

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